Disclaimer: This is just the blog of one guy with Behcet’s. To my knowledge, there have been no tests.
“Since I no longer had nicotine in my system suppressing my symptoms, the Behcet’s attacked my body with force.”
Nicotine and biochanin A, but not cigarette smoke, induce anti-inflammatory effects on keratinocytes and endothelial cells in patients with Behçet’s disease. Moreover, biochanin A is likely to exhibit similar and even more profound results than nicotine.
Cannabidiol (INN: CBD) is one of at least 113 active cannabinoids identified in cannabis. It is a major phytocannabinoid, accounting for up to 40% of the plant’s extract.
Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase.
Cannabidiol/CBD does not appear to have any intoxicating effects such as those caused by THC in marijuana, but may have effects on anxiety and an anti-psychotic effect.
Research suggests that Cannabidiol may exert some of its pharmacological action through its inhibition of fatty acid amide hydrolase (FAAH), which may in turn increase the levels of endocannabinoids, such as anandamide, produced by the body.[6] It has also been speculated that some of the metabolites of Cannabidiol/CBD have pharmacological effects that contribute to the biological activity of CBD.
Furthermore, (−)-CBD and (+)-CBD, as well as the natural metabolite 7-OH-CBD, inhibited fatty acid amide hydrolase with IC50 values of 27.5, 63.5, and 34.0 μM, respectively, but the 7-COOH-CBD metabolite was inactive (IC50 > 100 μM); also, anandamide uptake by rat basophilic leukemia cells was inhibited by (−)-CBD and by its 7-OH metabolite with IC50 values of 22.0 and ∼50 μM, respectively, as well as by (+)-CBD (IC50=17.0 μM) but 7-COOH-CBD was inactive (IC50 > 50 μm).
- http://online.liebertpub.com/doi/10.1089/can.2015.0012
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931556/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931556/
- https://www.ncbi.nlm.nih.gov/pubmed/17008886
- https://en.wikipedia.org/wiki/Cannabidiol
